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It contains a bicyclic ribose in which a methylene bridge connects the 2’-oxygen (O) and 4’-carbon (C)
Van Oorschot
24 (1995): 5020-5026
} 2'-O-4'-C-Locked-T(U) Phosphoramidite is a locked nucleic acid (LNA) phosphoramidite monomer for solid-phase oligonucleotide synthesis
"siRNA function in RNAi: a chemical modification analysis
1-N-Me-Pseudo UTP, 200mM Tris Salt Solution RNA (2'-O-TBDMS) Phosphoramidites It contains a bicyclic riboseN1 methyl pseudouridine 5 triphosphate (m1TP) is a chemically modified uridine nucleotide designed for enzymatic incorporation into RNA during IVT using RNA polymerases such as T7 RNA polymerase. m1TP is an N1 methylated derivative of pseudouridine that preserves base pairing properties while altering innate immune recognition. When substituted for uridine in IVT, m1 reduces activation of innate immune sensors and enhances translational efficiency of
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