PODS-GAA-Aeg(N3)-pSar6-OH C22H24N2O8 Transition Metal-Free Tryptophan-Selective Bioconjugation of

Transition Metal-Free Tryptophan-Selective Bioconjugation of Proteins

2-de]phthalazin-2(7H)-yl)methyl)carbamoyl)oxy)methyl)benzyl)(methyl)carbamate

1039/C3SC22015J

Modular Semisynthetic Approach to Generate T Cell-Dependent Bispecific Constructs from Recombinant IgG1 Antibodies

202314143 Keywords: Traceless Release

PODS-GAA-Aeg(N3)-pSar6-OH C22H24N2O8 Transition Metal-Free Tryptophan-Selective Bioconjugation ofReferences: Toda, N.; et al. Rapid, Stable, Chemoselective Labeling of Thiols with JuliaKocienski like Reagents: A Serum Stable Alternative to Maleimide Based Protein Conjugation. Angew. Chem., Int. Ed. (2013), 52, 12592 12596. DOI: 10. 1002 anie. 201306241 Keywords: PODS; Azido; Click Chemistry; Protein Conjugation Patterson, J. T.; et al. Improving the Serum Stability of Site Specific Antibody Conjugates with Sulfone Linkers. Bioconjugate Chem.